Investigation of immune-endocrine disorders in adolescent girls with anorexia nervosa

Amenorrhoea is the constant feature of Anorexia Nervosa (AN), caused by sharp metabolism reduction gonadotropines as compared with prepubertal level, but its exact mechanism unknown. Biochemical mediators, involved in this process, include cortisol, leptin, growth hormone (GH), insulin-like factor (IGF-1) and cytokines. Experimental investigation that produced fat cells, plays a role metabolic signal, which regulates hypothalamic – pituitary ovarian function. Functional activity reproductive axis depends on adequacy energy stocks. Leptin one most important maintenance homeostasis.Objective: To investigate immuno-endocrine disorders adolescent girls AN to optimize treatment tactics category patients.MethodsThe was carried out 3 groups girls: I - 59 diagnosed patients BMI =15,34+1,04; II 53 amenorrhea BMI=15.7+0,6, without AN; III control 20 healthy BMI=20.3+1,4.Measure serum concentration Insulin, Leptin, Neuropeptide Y (NPY), Tumor necrosis factor-α (TNF-α), GH, IGF-1, Gonadotropins, Estradiol (E2), Cortisol, Thyroxin (T3), Triiodothyronine (T4) Thyrotropin (TSH) ELISA out.Results discussionThe highest TNF-α, Cortisol levels, together minimum values NPY, IGF1, gonadotropins, E2, T3, T4, TSH were revealed anorectic (I group) comparison (II (III) groups.Absolute hypoleptinaemia low NPY levels testifies formation résistance leptin level. The GH IGF-1 groups, denoted GH-resistance.ConclusionThe presented results permit characterize neuro-endocrine-metabolic function regulation at AN: absolute hypoleptinemia, resistance GH- resistance, hypoinsulinism consequence starvation contrinsular effects hypogonadotropic hypogonadism thyroid status disorder form secondary hypothyreosis, dysfunction hypothalamic- axis. Neuro-endocrine-metabolic are associated impaired production cytokines damaging factors for functional state hypothalamic-pituitary-ovarian homeostasis. Objective: patients. BMI=20.3+1,4. Measure out. groups. Absolute GH-resistance.